Prey is a sci-fi thriller set aboard Talos I, a space station orbiting the moon in the year 2032. You play as Morgan Yu, waking to discover that the station has been overrun by hostile aliens and that you are the key subject of an experiment meant to alter humanity forever. Things have gone terribly wrong. The station's extraterrestrial threat is a living ecology bent on annihilating its prey, and you are now being hunted as one of the last remaining survivors.

Talos I itself is a lavish craft designed to reflect the corporate luxury of the 1960s, a symbol of private space enterprise at its height. Its interconnected pathways are non-linear, built to hide countless secrets. As you explore the station and dig into its dark history, you unravel clues you've left behind for yourself, piecing together the truth about your own past and the role you play in the plans of TranStar, the corporation behind it all.

Survival depends on using everything the station offers. Weapons, gadgets, blueprints and crafting tools let you build increasingly useful items to overcome dangerous obstacles. Beyond conventional tools, you can gain alien abilities, developing a distinct combination of powers while upgrading your own unique skills. The game leans into improvisation, letting you shape your approach to each threat rather than funneling you down a single path. How you play and what you become aboard Talos I is yours to decide, but the fate of everyone still alive on the station hangs on those choices.